The Manitoba Clinic is a private, multi-specialty medical clinic, founded in 1946. The Clinic is located adjacent to the Health Sciences Center in the west end of Winnipeg, at the southwest corner of Sherbrook Street and McDermot Avenue.

The Clinic currently occupies 70,000 square feet, with capacity to add an additional 60,000 square feet which is now being planned. As one of Canada's largest medical clinics, the facility comprises more than 75 physicians, mainly specialists. Manitoba Clinic offers a diverse range of professional medical programs and health care services. A number of commercial tenants such as a pharmacy, optician, delicatessen, and a hearing aid center occupy the main floor of the Clinic complex.